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News

February 2024

We published “SLIDE: Significant Latent factor Interaction Discovery and Exploration across biological domains” in Nature Methods

December 2023

We published “From bench to bedside via bytes: multi-omic immunoprofiling and integration using machine learning and network approaches” in Human Vaccines and Immunotherapeutics

December 2023

We contributed to “PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition”, which was published in Cell Reports Medicine

November 2023

We contributed to “SARS-CoV-2 mRNA vaccines induce greater complement activation and decreased viremia and Nef antibodies in men with HIV-1”, which was published in The Journal of Infectious Diseases

October 2023

Jishnu gave an invited talk at BMES 2023 on, "Elucidating humoral profiles associated with Schistosomiasis pathogenesis using interpretable machine learning".

August 2023

We contributed to “Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A”, which got published in the Journal of Experimental Medicine

July 2023

We contributed to “The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells”, which got published in Immunity

August 2023

We published “Cell Type-Specific Biomarkers of Systemic Sclerosis Disease Severity Capture Cell-Intrinsic and Cell-Extrinsic Circuits” in Arthritis & Rheumatology

October 2023

Jishnu gave an invited talk at BMES 2023 on, "Significant latent factor interaction discovery and exploration across biological domains".

June 2023

We published“Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19" in Cell Reports

May 2023

Jishnu gave an invited talk at FASEB Autoimmunity 2023 on , "Multi-dimensional integration of protein interactomes with genomic and molecular data discover distinct RA endotypes".

March 2023

Jishnu gave an invited talk at Cold Spring Harbor Laboratory Network Biology Meeting 2023 on "Uncovering immunomodulatory molecular phenotypes in infectious disease using networks".

April 2023

Jishnu gave an invited talk at Cold Spring Harbor Laboratory Systems Immunology Meeting 2023 on "Multi-dimensional integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes".

April 2023

We contributed to “Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates”, which got published in the Cell Reports

February 2023

We contributed to “High-dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma”, which got published in the The Journal of Trauma and Acute Care Surgery.

October 2022

Jishnu is a Co-I at Systemic Sclerosis Center for Research and Translation which provides machine learning and network systems expertise to investigators working on SSc, SSc-ILD and SSc-PAH. 

October 2022

Jishnu is a Co-I on the U01 Grant funded to characterize cell-intrinsic and cell-extrinsic signaling circuits in ocular disorders. 

September 2022

Jishnu gave an invited talk at the Banff-CST Joint Transplant and Pathology Summit titled “Machine learning in clinical decision making in transplant biology”

August 2022

August 2022

Jishnu gave a talk at International Workshop on Scleroderma 2022 in Boston.

July 2022

Jishnu was invited to give a talk at ISMB 2022 on the topic “A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation”

July 2022

Scleroderma CDMRO Award was given to Jishnu (role: Co-I)

July 2022

The Philadelphia Enquirer covered our very recent publication on COVID-19. Find the link to the article here! 

July 2022

Our work got covered in Pittsburgh's Action 4 News "4 Your Health: Studying COVID-19 antibody patterns". Have a look here

July 2022

Jishnu becomes a co-Director for the Systems Immunology Core (funded by NIAMS P50) which will perform machine learning and network systems analyses on multi-modal datasets in the context of SSc.

June 2022

Our paper Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients got accepted in Metabolites

June 2022

Our paper High Dimensional Multi-omics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients with TBI got accepted in Annals of Surgery

June 2022

We published Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19 in Cell Press (Link)

May 2022

We found out that our NIAID Flu Systems Vaccinology R01 (Role: MPI, other PIs: Alcorn, Singh, Zimmerman) will be funded. Here is the link to NIH RePORTER

May 2022

We participated in a Pitt-Case Western CFAR application that was funded by NIAID Rustbelt (Role: co-I)

May 2022

We contributed to Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3  which got published in the Nature Immunology (link)

April 2022

Our CIHR grant (Role: co-I, PI: Konvalinka) was funded.

April 2022

We published a manuscript in Cell Reports Medicine demonstrating how integrating bulk RNA-seq data with protein networks can uncover signatures underlying rejection in pediatric liver transplantation. (link)

March 2022

Our DoD grant (Role: co-I, PIs: Lafyatis and Singh) looking at multi-omic signatures of scleroderma disease severity was funded.

March 2022

Our Essential Regression manuscript was published in Patterns. (link)

September 2021

A NIAID R01 we participated in (Role: co-I, PIs: Rinaldo and Mailliard) looking at COVID-19 vaccine responses in HIV individuals was funded.

September 2021

We received a 5-year NHGRI U01 1U01HG012041-01 (Role: MPI, Other PIs: Singh, Sahni). Link on NIH Reporter 

August 2021

We received a 5-year NIAID New Innovator DP2 Award 1DP2AI164325-01 (Role: PI). Link on NIH Reporter

June 2021

An NIDDK dkNET New Investigator Pilot Program in Bioinformatics grant that we participated in has been funded (Role: co-I, PI: Joglekar).

June 2021

We contributed to Mechanisms of impaired lung development and ciliation in Mannosidase-1-alpha-2 (Man1a2) mutants in Frontiers in Physiology

April 2021

Jishnu gave a talk at the 2021 Cold Spring Harbor Systems Immunology Meeting

April 2021

A Department of Defense Idea Development Award grant that we participated in has been funded (Role: co-I, PI: Lafyatis).

March 2021

Jishnu gave a talk at the 2021 Cold Spring Harbor Networks Meeting

October 2020

We published Mining for humoral correlates of HIV control and latent reservoir size in PLoS pathogens

September 2020

August 2020

We are now supported by a Collaborative Research Agreement with the University of Brussels Center for Research In Immunology (Role: PI)!

July 2020

July 2020

June 2020

We received a pilot Covid-19 grant from the UPMC-ITTC (Role: PI)!

May 2020

We received a PACER (Pittsburgh Autoimmunity Center for Excellence in Research) grant (Role: PI)!

March 2020

March 2020

February 2020

We published Antibody Fc Glycosylation Discriminates Between Latent and Active Tuberculosis in The Journal of Infectious Diseases

January 2020

The Das Systems Immunology Lab is now supported by Center for Systems Immunology Startup Funds!

January 2020

The lab is now open! We look forward to exciting science in the future!

                                                                                            Current as of December 2023

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