Jishnu is a Co-I at Systemic Sclerosis Center for Research and Translation which provides machine learning and network systems expertise to investigators working on SSc, SSc-ILD and SSc-PAH.
Jishnu is a Co-I on the U01 Grant funded to characterize cell-intrinsic and cell-extrinsic signaling circuits in ocular disorders.
Jishnu gave an invited talk at the Banff-CST Joint Transplant and Pathology Summit titled “Machine learning in clinical decision making in transplant biology”
We published A supervised take on dimensionality reduction via hybrid subset selection in Patterns (Cell Press)
Jishnu gave a talk at International Workshop on Scleroderma 2022 in Boston.
Jishnu was invited to give a talk at ISMB 2022 on the topic “A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation”
Scleroderma CDMRO Award was given to Jishnu (role: Co-I)
The Philadelphia Enquirer covered our very recent publication on COVID-19. Find the link to the article here!
Our work got covered in Pittsburgh's Action 4 News "4 Your Health: Studying COVID-19 antibody patterns". Have a look here
Jishnu becomes a co-Director for the Systems Immunology Core (funded by NIAMS P50) which will perform machine learning and network systems analyses on multi-modal datasets in the context of SSc.
Our paper Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients got accepted in Metabolites
Our paper High Dimensional Multi-omics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients with TBI got accepted in Annals of Surgery
We published Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19 in Cell Press (Link)
We found out that our NIAID Flu Systems Vaccinology R01 (Role: MPI, other PIs: Alcorn, Singh, Zimmerman) will be funded. Here is the link to NIH RePORTER
We participated in a Pitt-Case Western CFAR application that was funded by NIAID Rustbelt (Role: co-I)
We contributed to Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3 which got published in the Nature Immunology (link)
Our CIHR grant (Role: co-I, PI: Konvalinka) was funded.
We published a manuscript in Cell Reports Medicine demonstrating how integrating bulk RNA-seq data with protein networks can uncover signatures underlying rejection in pediatric liver transplantation. (link)
Our DoD grant (Role: co-I, PIs: Lafyatis and Singh) looking at multi-omic signatures of scleroderma disease severity was funded.
A NIAID R01 we participated in (Role: co-I, PIs: Rinaldo and Mailliard) looking at COVID-19 vaccine responses in HIV individuals was funded.
We received a 5-year NHGRI U01 1U01HG012041-01 (Role: MPI, Other PIs: Singh, Sahni). Link on NIH Reporter
We received a 5-year NIAID New Innovator DP2 Award 1DP2AI164325-01 (Role: PI). Link on NIH Reporter
An NIDDK dkNET New Investigator Pilot Program in Bioinformatics grant that we participated in has been funded (Role: co-I, PI: Joglekar).
We contributed to Mechanisms of impaired lung development and ciliation in Mannosidase-1-alpha-2 (Man1a2) mutants in Frontiers in Physiology
Jishnu gave a talk at the 2021 Cold Spring Harbor Systems Immunology Meeting
A Department of Defense Idea Development Award grant that we participated in has been funded (Role: co-I, PI: Lafyatis).
Jishnu gave a talk at the 2021 Cold Spring Harbor Networks Meeting
We published Mining for humoral correlates of HIV control and latent reservoir size in PLoS pathogens
We contributed to Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study, which was published in the Journal of the American Society of Nephrology
We are now supported by a Collaborative Research Agreement with the University of Brussels Center for Research In Immunology (Role: PI)!
We published Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination in Science Translational Medicine
We received a pilot Covid-19 grant from the UPMC-ITTC (Role: PI)!
We received a PACER (Pittsburgh Autoimmunity Center for Excellence in Research) grant (Role: PI)!
We contributed to Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells, which was published in PLoS pathogens
We contributed to Epigenetic basis for monocyte dysfunction in patients with severe alcoholic hepatitis, which was published in the Journal of Hepatology
We published Antibody Fc Glycosylation Discriminates Between Latent and Active Tuberculosis in The Journal of Infectious Diseases
The Das Systems Immunology Lab is now supported by Center for Systems Immunology Startup Funds!
The lab is now open! We look forward to exciting science in the future!