News
February 2024
We published “SLIDE: Significant Latent factor Interaction Discovery and Exploration across biological domains” in Nature Methods
December 2023
We published “From bench to bedside via bytes: multi-omic immunoprofiling and integration using machine learning and network approaches” in Human Vaccines and Immunotherapeutics
December 2023
We contributed to “PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition”, which was published in Cell Reports Medicine
November 2023
We contributed to “SARS-CoV-2 mRNA vaccines induce greater complement activation and decreased viremia and Nef antibodies in men with HIV-1”, which was published in The Journal of Infectious Diseases
October 2023
Jishnu gave an invited talk at BMES 2023 on, "Elucidating humoral profiles associated with Schistosomiasis pathogenesis using interpretable machine learning".
August 2023
We contributed to “Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A”, which got published in the Journal of Experimental Medicine
July 2023
We contributed to “The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells”, which got published in Immunity
August 2023
We published “Cell Type-Specific Biomarkers of Systemic Sclerosis Disease Severity Capture Cell-Intrinsic and Cell-Extrinsic Circuits” in Arthritis & Rheumatology
October 2023
Jishnu gave an invited talk at BMES 2023 on, "Significant latent factor interaction discovery and exploration across biological domains".
June 2023
We published“Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19" in Cell Reports
May 2023
Jishnu gave an invited talk at FASEB Autoimmunity 2023 on , "Multi-dimensional integration of protein interactomes with genomic and molecular data discover distinct RA endotypes".
March 2023
Jishnu gave an invited talk at Cold Spring Harbor Laboratory Network Biology Meeting 2023 on "Uncovering immunomodulatory molecular phenotypes in infectious disease using networks".
April 2023
Jishnu gave an invited talk at Cold Spring Harbor Laboratory Systems Immunology Meeting 2023 on "Multi-dimensional integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes".
April 2023
We contributed to “Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates”, which got published in the Cell Reports
February 2023
We contributed to “High-dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma”, which got published in the The Journal of Trauma and Acute Care Surgery.
October 2022
Jishnu is a Co-I at Systemic Sclerosis Center for Research and Translation which provides machine learning and network systems expertise to investigators working on SSc, SSc-ILD and SSc-PAH.
October 2022
Jishnu is a Co-I on the U01 Grant funded to characterize cell-intrinsic and cell-extrinsic signaling circuits in ocular disorders.
September 2022
Jishnu gave an invited talk at the Banff-CST Joint Transplant and Pathology Summit titled “Machine learning in clinical decision making in transplant biology”
August 2022
We published A supervised take on dimensionality reduction via hybrid subset selection in Patterns (Cell Press)
August 2022
Jishnu gave a talk at International Workshop on Scleroderma 2022 in Boston.
July 2022
Jishnu was invited to give a talk at ISMB 2022 on the topic “A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation”
July 2022
Scleroderma CDMRO Award was given to Jishnu (role: Co-I)
July 2022
The Philadelphia Enquirer covered our very recent publication on COVID-19. Find the link to the article here!
July 2022
Our work got covered in Pittsburgh's Action 4 News "4 Your Health: Studying COVID-19 antibody patterns". Have a look here
July 2022
Jishnu becomes a co-Director for the Systems Immunology Core (funded by NIAMS P50) which will perform machine learning and network systems analyses on multi-modal datasets in the context of SSc.
June 2022
Our paper Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients got accepted in Metabolites
June 2022
Our paper High Dimensional Multi-omics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients with TBI got accepted in Annals of Surgery
June 2022
We published Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19 in Cell Press (Link)
May 2022
We found out that our NIAID Flu Systems Vaccinology R01 (Role: MPI, other PIs: Alcorn, Singh, Zimmerman) will be funded. Here is the link to NIH RePORTER
May 2022
We participated in a Pitt-Case Western CFAR application that was funded by NIAID Rustbelt (Role: co-I)
May 2022
We contributed to Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3 which got published in the Nature Immunology (link)
April 2022
Our CIHR grant (Role: co-I, PI: Konvalinka) was funded.
April 2022
We published a manuscript in Cell Reports Medicine demonstrating how integrating bulk RNA-seq data with protein networks can uncover signatures underlying rejection in pediatric liver transplantation. (link)
March 2022
Our DoD grant (Role: co-I, PIs: Lafyatis and Singh) looking at multi-omic signatures of scleroderma disease severity was funded.
September 2021
A NIAID R01 we participated in (Role: co-I, PIs: Rinaldo and Mailliard) looking at COVID-19 vaccine responses in HIV individuals was funded.
September 2021
We received a 5-year NHGRI U01 1U01HG012041-01 (Role: MPI, Other PIs: Singh, Sahni). Link on NIH Reporter
August 2021
We received a 5-year NIAID New Innovator DP2 Award 1DP2AI164325-01 (Role: PI). Link on NIH Reporter
June 2021
An NIDDK dkNET New Investigator Pilot Program in Bioinformatics grant that we participated in has been funded (Role: co-I, PI: Joglekar).
June 2021
We contributed to Mechanisms of impaired lung development and ciliation in Mannosidase-1-alpha-2 (Man1a2) mutants in Frontiers in Physiology
April 2021
Jishnu gave a talk at the 2021 Cold Spring Harbor Systems Immunology Meeting
April 2021
A Department of Defense Idea Development Award grant that we participated in has been funded (Role: co-I, PI: Lafyatis).
March 2021
Jishnu gave a talk at the 2021 Cold Spring Harbor Networks Meeting
October 2020
We published Mining for humoral correlates of HIV control and latent reservoir size in PLoS pathogens
September 2020
We contributed to Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study, which was published in the Journal of the American Society of Nephrology
August 2020
We are now supported by a Collaborative Research Agreement with the University of Brussels Center for Research In Immunology (Role: PI)!
July 2020
July 2020
We published Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination in Science Translational Medicine
June 2020
We received a pilot Covid-19 grant from the UPMC-ITTC (Role: PI)!
May 2020
May 2020
We received a PACER (Pittsburgh Autoimmunity Center for Excellence in Research) grant (Role: PI)!
March 2020
We contributed to Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells, which was published in PLoS pathogens
March 2020
We contributed to Epigenetic basis for monocyte dysfunction in patients with severe alcoholic hepatitis, which was published in the Journal of Hepatology
February 2020
We published Antibody Fc Glycosylation Discriminates Between Latent and Active Tuberculosis in The Journal of Infectious Diseases
January 2020
The Das Systems Immunology Lab is now supported by Center for Systems Immunology Startup Funds!
January 2020
The lab is now open! We look forward to exciting science in the future!